(verbatim from application) The Study of Osteoporotic Fractures (SOF) is a community-based prospective study in a cohort of 9,704 older women. SOF has comprehensive data about osteoporosis risk factors, along with an archive of serum, bully coat and urine specimens. Data from SOF have served for: (1) developing osteoporosis guidelines, (2) estimating the cost-effectiveness of screening for osteoporosis, and (3) planning trials of osteoporosis therapies. We propose to renew SOF to sustain this unique resource and to pursue several new hypotheses. Our preliminary findings suggest that BMD may lose predictive value for hip fractures after 4-5 years. We will study the long-term predictive value of BMD, and other risk factors, after 10-15 years; substantial declines would strongly effect guidelines concerning the frequency and cost-effectiveness of screening. We recently discovered that women with osteoporosis have a decreased risk of breast cancer, suggesting that these conditions share common etiologies. We will begin the search for these links by investigating whether endogenous sex steroids are associated with breast cancer, and whether other indices of osteoporosis, such as height loss, low ultrasound values, or incident fractures, indicate a lower risk of breast cancer. We have found that, contrary to previous beliefs, the rate of bone loss increases with age in Caucasian and African-American women. Elderly women also lose muscle mass as they age. We have also shown that mild chronic metabolic acidosis of dietary origin affects bone and causes negative nitrogen balance. We propose to test whether diet-induced metabolic acidosis, amplified by the normal age-related decline in renal function, is an important cause of loss of bone and muscle mass in elderly women, and is a risk factor for hip fracture. Declines in visual functions, such as contrast sensitivity, increase the risk of hip, wrist and humerus fractures and falls. Uncorrected refractive error and specific eye diseases, such as cataracts, glaucoma, and age-related macular degeneration, are common in elderly women. We will test the hypothesis that these common and potentially treatable eye diseases increase fall and fracture risk. Besides their scientific value, these findings may influence clinical guidelines and Medicare coverage for preventive eye care. Finally, there are contradictory findings about the relationship between estrogen receptor (ER) genotypes and bone mass and breast cancer, or even if ER variations have any biological effects. We propose using our archived DNA specimens and existing data about hip and vertebral fractures, breast cancer, bone mass, serum sex hormones and lipoproteins to determine whether these ER variations have biological importance.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR035583-15
Application #
6137308
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Mcgowan, Joan A
Project Start
1986-02-01
Project End
2001-12-31
Budget Start
2000-01-01
Budget End
2000-12-31
Support Year
15
Fiscal Year
2000
Total Cost
$271,036
Indirect Cost
Name
Kaiser Foundation Research Institute
Department
Type
DUNS #
City
Oakland
State
CA
Country
United States
Zip Code
94612
Eurelings, Lisa Sm; van Dalen, Jan Willem; Ter Riet, Gerben et al. (2018) Apathy and depressive symptoms in older people and incident myocardial infarction, stroke, and mortality: a systematic review and meta-analysis of individual participant data. Clin Epidemiol 10:363-379
Bonham, Luke W; Evans, Daniel S; Liu, Yongmei et al. (2018) Neurotransmitter Pathway Genes in Cognitive Decline During Aging: Evidence for GNG4 and KCNQ2 Genes. Am J Alzheimers Dis Other Demen 33:153-165
Diem, Susan J; Vo, Tien N; Langsetmo, Lisa et al. (2018) Impact of Competing Risk of Mortality on Association of Cognitive Impairment With Risk of Hip Fracture in Older Women. J Bone Miner Res 33:1595-1602
Ensrud, Kristine E; Kats, Allyson M; Schousboe, John T et al. (2018) Frailty Phenotype and Healthcare Costs and Utilization in Older Women. J Am Geriatr Soc 66:1276-1283
Black, Dennis M; Cauley, Jane A; Wagman, Rachel et al. (2018) The Ability of a Single BMD and Fracture History Assessment to Predict Fracture Over 25 Years in Postmenopausal Women: The Study of Osteoporotic Fractures. J Bone Miner Res 33:389-395
Mariani, Sara; Tarokh, Leila; Djonlagic, Ina et al. (2018) Evaluation of an automated pipeline for large-scale EEG spectral analysis: the National Sleep Research Resource. Sleep Med 47:126-136
LeBlanc, Erin S; Rizzo, Joanne H; Pedula, Kathryn L et al. (2018) Long-Term Weight Trajectory and Risk of Hip Fracture, Falls, Impaired Physical Function, and Death. J Am Geriatr Soc 66:1972-1979
Byers, Amy L; Lui, Li-Yung; Vittinghoff, Eric et al. (2018) Burden of Depressive Symptoms Over 2 Decades and Risk of Nursing Home Placement in Older Women. J Am Geriatr Soc 66:1895-1901
Schousboe, John T; Kats, Allyson M; Langsetmo, Lisa et al. (2018) Associations of recent weight loss with health care costs and utilization among older women. PLoS One 13:e0191642
Diem, Susan J; Lui, Li-Yung; Langsetmo, Lisa et al. (2018) Effects of Mobility and Cognition on Maintenance of Independence and Survival Among Women in Late Life. J Gerontol A Biol Sci Med Sci 73:1251-1257

Showing the most recent 10 out of 296 publications