The broad objective of this application is to facilitate study of visual system function in health and in binding disease with the aim of preventing, mitigating, or curing such disease through the application of the most sophisticated available techniques, including the methods used in molecular biology and molecular genetics. Four support modules will provide these: . Imaging and Computer Module (computer-aided image and data acquisition and analysis); . Molecular Biology Module (molecular localization in tissues using phosphoimaging, DNA sequencing and gene cloning); . Targeted Mutagenesis and Transgenic Animal Module (targeted mutagenesis and development of transgenic animal models); and . In situ Hybridization Module (in Situ hybridization, combined in situ hybridization and immunocytochemistry, and in situ PCR). This application is a competing renewal of a Core Vision Research Grant submitted by the Principal Investigator and 23 other funded investigators. Twelve are NEI-funded, and seven others are funded by non-NIH sources. Of the latter seven, two are submitting NEI R01 renewals, and three are preparing new NEI RO1 applications.

National Institute of Health (NIH)
National Eye Institute (NEI)
Center Core Grants (P30)
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Special Emphasis Panel (ZEY1-VSN (02))
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University of California San Francisco
Schools of Medicine
San Francisco
United States
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Nachury, Maxence V (2018) The molecular machines that traffic signaling receptors into and out of cilia. Curr Opin Cell Biol 51:124-131
Kim, Jean; Kudisch, Max; da Silva, Nina Rosa Konichi et al. (2018) Long-term intraocular pressure reduction with intracameral polycaprolactone glaucoma devices that deliver a novel anti-glaucoma agent. J Control Release 269:45-51
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Feinstein, Max; Moussa, Kareem; Han, Ying (2018) Ab Interno Tube Occlusion for Postoperative Hypotony in a Patient With an Ahmed Glaucoma Drainage Device. J Glaucoma 27:e61-e63
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Lew, Young Ju; Rinella, Nicholas; Qin, Jia et al. (2018) High-resolution Imaging in Male Germ Cell-Associated Kinase (MAK)-related Retinal Degeneration. Am J Ophthalmol 185:32-42
Lu, Jianmin; Luo, Lingyu; Huang, Deqiang et al. (2018) Photoreceptor Protection by Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF). eNeuro 5:
Lamy, Ricardo; Chan, Elliot; Lee, On-Tat et al. (2018) 880 kHz ultrasound treatment for drug delivery to the vitreous humor. Am J Transl Res 10:3162-3170
Ahn, Yoomin; Lamy, Ricardo; Darling, Cynthia L et al. (2018) Photochemical crosslinking of caries-affected dentin combined with total- or self-etch systems. Am J Transl Res 10:2990-2995
Branham, Kari; Guru, Aditya A; Kozak, Igor et al. (2018) Identification of Novel Deletions as the Underlying Cause of Retinal Degeneration in Two Pedigrees. Adv Exp Med Biol 1074:229-236

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