? Radiobiology and Imaging Program (RBI) The Radiobiology and Imaging Program (RBI) seeks to advance the understanding of the interaction of ionizing and non-ionizing radiation with cancer and normal tissues. RBI addresses the cancer burden within our catchment area through collaboration with our Community Outreach and Engagement (COE). Scientific Aims are to: 1) Develop and characterize agents to improve cancer therapy with radiation; 2) Investigate radiobiological or imaging methods of altering or interrogating the immune environment to improve therapeutic response; 3) Gain a deeper understanding of the tumor microenvironment (TME) and metabolism with the aim to leverage this understanding to improve therapeutic response; 4) Develop novel imaging to optimally guide cancer care; and 5) Understand the biological effects of protons to optimize their clinical use and determine which patients will benefit most from proton beam therapy. The Program is led by Amit Maity, MD, PhD, Professor and Executive Vice-Chair of the Department of Radiation Oncology, and Daniel Pryma, MD, Associate Professor of Radiology and Chief of the Division of Nuclear Medicine. Drs. Maity and Pryma are NCI-funded researchers who bring their scientific vision to this Program, which is focused on basic and translational research and the development of investigator-initiated trials. Since the last renewal, the Program Leaders recruited new junior and senior scientists, enhanced collaborative peer-reviewed funding, and more than doubled accruals to interventional clinical trials, especially investigator-initiated trials (which constitute 91.6% of interventional accruals). Drs. Maity and Pryma expanded the Program's focus on imaging modalities and theranostics and further enhanced the integration and interplay between radiobiology and imaging in RBI. A major development has been the substantial expansion of both translational and clinical studies of proton therapy. RBI has critical interactions with other ACC Programs including Tumor Biology, Immunobiology, Cancer Therapeutics, Breast Cancer, Cancer Control, Tobacco and Environmental Carcinogenesis, and Pediatric Oncology. The 44 Program members represent seven departments from four schools at Penn. RBI members have $12M in research grant funding (annual direct costs), of which $10.9M is peer-reviewed and $7M is NCI-funded. There were 654 cancer-related publications authored by Program members during the project period. Of these, 27% are intra-Programmatic, 35% are inter-Programmatic and 64% are multi- institutional. RBI has 36 R01-equivalents. Program members accrued 1,476 subjects to interventional trials, and 3,611 subjects to non-interventional trials.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016520-45
Application #
10088748
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
1997-01-15
Project End
2025-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
45
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Huang, Mo; Wang, Jingshu; Torre, Eduardo et al. (2018) SAVER: gene expression recovery for single-cell RNA sequencing. Nat Methods 15:539-542
Yam, Clinton; Xu, Xiaowei; Davies, Michael A et al. (2018) A Multicenter Phase I Study Evaluating Dual PI3K and BRAF Inhibition with PX-866 and Vemurafenib in Patients with Advanced BRAF V600-Mutant Solid Tumors. Clin Cancer Res 24:22-32
Onorati, Angelique V; Dyczynski, Matheus; Ojha, Rani et al. (2018) Targeting autophagy in cancer. Cancer 124:3307-3318
Rebecca, Vito W; Nicastri, Michael C; Fennelly, Colin et al. (2018) PPT1 promotes tumor growth and is the molecular target of chloroquine derivatives in cancer. Cancer Discov :
Garfall, Alfred L; Stadtmauer, Edward A; Hwang, Wei-Ting et al. (2018) Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma. JCI Insight 3:
Jang, Jeong Hoon; Manatunga, Amita K; Taylor, Andrew T et al. (2018) Overall indices for assessing agreement among multiple raters. Stat Med 37:4200-4215
Scheel, John R; Kim, Eunhee; Partridge, Savannah C et al. (2018) MRI, Clinical Examination, and Mammography for Preoperative Assessment of Residual Disease and Pathologic Complete Response After Neoadjuvant Chemotherapy for Breast Cancer: ACRIN 6657 Trial. AJR Am J Roentgenol 210:1376-1385
Romero, Sally A D; Brown, Justin C; Bauml, Joshua M et al. (2018) Barriers to physical activity: a study of academic and community cancer survivors with pain. J Cancer Surviv 12:744-752
Hinderer, Christian; Katz, Nathan; Buza, Elizabeth L et al. (2018) Severe Toxicity in Nonhuman Primates and Piglets Following High-Dose Intravenous Administration of an Adeno-Associated Virus Vector Expressing Human SMN. Hum Gene Ther 29:285-298
Li, Jinyang; Byrne, Katelyn T; Yan, Fangxue et al. (2018) Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy. Immunity 49:178-193.e7

Showing the most recent 10 out of 1047 publications