The Core will provide quantitative image processing and analysis support for the four research projects and other cores. A common theme that spans all the research projects is the use of anatomic and functional data derived from imaging studies acquired before and during therapy to better individualize patient treatments and to adapt to changes observed during the course of therapy. Projects will rely on data from anatomic and functional imaging studies to set initial criteria for plan optimization and for re-optimization during the treatment course using updated information and estimates of delivered dose; use in-room volumetric imaging during and between treatments to update decisions about patient positioning and immobilization over the course of therapy;acquire and analyze image data to help predict tumor response early in the treatment course;and use image data to help quantify normal tissue function both prior to and during therapy to individualize the estimation of risk. The Core will provide the image processing and analysis in the different projects as they rely on manual and automated image segmentation and data reduction, rigid and deformable registration and integration of multimodality and time-series image data and accumulated dose distributions, and multi-parameter estimation and statistical analysis. While some of these tasks can be automated, some are labor intensive or involve manual initialization. The core will perform the necessary automated processing and analysis, and will perform the manual assessments and validation for these tasks, using robust and efficient visualization tools. In addition to standard processing and analysis tasks, the core will provide ongoing development, implementation and validation of new and novel techniques to handle the complex set of image, dose, and functional information that the projects will acquire and produce, and it will provide the robust storage and retrieval infrastructure required for the program project.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
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Subcommittee G - Education (NCI)
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University of Michigan Ann Arbor
Ann Arbor
United States
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Ohri, Nitin; Tomé, Wolfgang A; Méndez Romero, Alejandra et al. (2018) Local Control After Stereotactic Body Radiation Therapy for Liver Tumors. Int J Radiat Oncol Biol Phys :
Mendiratta-Lala, Mishal; Gu, Everett; Owen, Dawn et al. (2018) Imaging Findings Within the First 12 Months of Hepatocellular Carcinoma Treated With Stereotactic Body Radiation Therapy. Int J Radiat Oncol Biol Phys 102:1063-1069
Wang, Shulian; Campbell, Jeff; Stenmark, Matthew H et al. (2018) A model combining age, equivalent uniform dose and IL-8 may predict radiation esophagitis in patients with non-small cell lung cancer. Radiother Oncol 126:506-510
Sapir, Eli; Tao, Yebin; Schipper, Matthew J et al. (2018) Stereotactic Body Radiation Therapy as an Alternative to Transarterial Chemoembolization for Hepatocellular Carcinoma. Int J Radiat Oncol Biol Phys 100:122-130
Hawkins, Peter G; Boonstra, Philip S; Hobson, Stephen T et al. (2018) Prediction of Radiation Esophagitis in Non-Small Cell Lung Cancer Using Clinical Factors, Dosimetric Parameters, and Pretreatment Cytokine Levels. Transl Oncol 11:102-108
Sun, Yilun; Hawkins, Peter G; Bi, Nan et al. (2018) Serum MicroRNA Signature Predicts Response to High-Dose Radiation Therapy in Locally Advanced Non-Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys 100:107-114
Kong, Feng-Ming Spring; Li, Ling; Wang, Weili et al. (2018) Greater reduction in mid-treatment FDG-PET volume may be associated with worse survival in non-small cell lung cancer. Radiother Oncol :
Shilkrut, Mark; Sapir, Eli; Hanasoge, Sheela et al. (2018) Phase I Trial of Dose-escalated Whole Liver Irradiation With Hepatic Arterial Fluorodeoxyuridine/Leucovorin and Streptozotocin Followed by Fluorodeoxyuridine/Leucovorin and Chemoembolization for Patients With Neuroendocrine Hepatic Metastases. Am J Clin Oncol 41:326-331
Jackson, William C; Tao, Yebin; Mendiratta-Lala, Mishal et al. (2018) Comparison of Stereotactic Body Radiation Therapy and Radiofrequency Ablation in the Treatment of Intrahepatic Metastases. Int J Radiat Oncol Biol Phys 100:950-958
Miften, Moyed; Vinogradskiy, Yevgeniy; Moiseenko, Vitali et al. (2018) Radiation Dose-Volume Effects for Liver SBRT. Int J Radiat Oncol Biol Phys :

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