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anonymous on The Rise and Fall of the Dominant FewThe New York schools, like Mount Sinai, are some of the most cutthroat places to work. They have no problem with reducing your salary down to 10% if your grants...
BD on A study to improve the fit of HIV prevention methodsFinally the kind of research that I want my government to pay for! And it is already in the stage of clinical trials. :)
random observer on Seattle-Lausanne-Kampala CTUThis grant has reviewer comments in Abstract! How could it be funded at <10% success rate if 'Reviewers express a strong concern ...
PI on The Rich and the Rest Looking at the R01 distribution, the trend for 2014 & 2015 does not look that hot.
Shan on Brain mast cells and Chronic Fatigue SyndromeHi Jan Marie. I’m not a medical professional, but I encourage you to join the Mast Cell Activation Disorders Forum on Facebook. There is a lot of good information there.
Robert W Townsend on Regulation Of Intracellular Iron MetabolismHello Ms. Rouoault, I am a published Neurobiochemistry researcher recently diagnosed with Polycythemia. I cannot do Phlebotomy treatment due to blood-iron complications. I came upon the Ghosh et al. s...
smartalec on Research Dollars are Decreasing for the Most Funded "Keywords"?Seems its time for an update on this topic following the wave of omics profiling papers...
Tony Zheng on FEND for TBGreeting! We are a raw bio-materials provider and are interested in developing TB RDT kit. To be mentioned, we have our own subsidiary with R&D strength and capability. Are we...
Pharmacological Probes based on mitragynine pseudoindoxylThe ideal pain medication would be devoid of the serious side effects associated with the currently used opioids (respiratory depression, constipation, dependence, addiction). Mitragynine is a corynanthe-type indole alkaloid isolated...
Structure of the GABA A Receptor Binding SitesGamma-aminobutyric acid type A receptors (GABAARs) mediate synaptic inhibition in the brain and the actions of several clinically important drugs, including benzodiazepines, barbiturates, ethanol and anesthetics. Several mutations in the...
Yeast RNA VirologyWe have described two dsRNA viruses (L-A and L-BC) and two ssRNA replicons (20S RNA and 23S RNA) in the yeast Saccharomyces cerevisiae. M dsRNA is a satellite of L-A...
Pathobiology of Actinobacillus LeukotoxinActinobacillus actinomycetemcomitans, a major pathogen in certain human periodontal diseases, elaborates a potent leukotoxin. This polypeptide kills human neutrophils, monocytes and T lymphocytes and may impair host antibacterial resistance by...
A novel protein export chaperone of Mycobacterium tuberculosisMycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), represents a severe world health crisis (4,000 TB deaths daily). A better understanding of Mtb biology and pathogenesis will drive development...
Memory T Cell Cosigning Pathways in Sepsis-Induced Immune DysregulationRecent studies assessing the immune phenotypes and functionality of septic patients have increased our understanding of the immune dysregulation that occurs during sepsis. The new paradigm suggests that the balance...
Unmet needs for specific subsets of EGFR mutated lung cancerLung cancer is the leading cause of cancer-related mortality for both men and women in the United States. The number of new cases of lung cancer exceeds 220,000 yearly; with...
Mechanisms Mediating Osseointegration of 3D Printed Titanium ConstructsThis proposal addresses the growing clinical need in dentistry and orthopaedics for materials that enable rapid osseointegration and earlier loading times for implants in bone that has been compromised by...
The postdoctoral training period is nearly essential for all research scientists who aspire to lead a research laboratory in a university or non-profit research center. To characterize the transition of scientists from postdoc to established PI, we previously conducted an analysis of how many postdocs with a NIH-sponsored F32 fellowship went on to become PIs of a R-esearch grant. In 2006, NIH int...
Previously, we calculated the fraction of the R01 grant pool that each institution has obtained in 2013, and how this fraction has changed over time. We now wanted to perform a complementary analysis, determining institutional variability in the length of time that individual PIs are able to maintain NIH grant funding. This analysis would be of interest to university administrators who want to rec...
In our database, for any grant we report "Related Projects" that are renewals of ongoing projects from individual investigators. We wanted to improve this by identifying "Related Projects" more generally in which we group different grants based on the text in the abstract. We analyzed the similarities of 2013 NIH grant abstracts with lengths of at least 100 words (disregarding the public health r...
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